ホーム研究内容研究室メンバー研究実績写真地図・アクセス招待セミナーリンク

研究実績


  • 2016
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2016年研究業績

    Jheng H-F, Hirotsuka M, Goto T, Shibata M, Matsumura Y, Kawada T.
  • Dietary Low-Fat Soy Milk Powder Retards Diabetic Nephropathy Progression via Inhibition of Renal Fibrosis and Renal Inflammation
    Mol Nutr Food Res In press
  • Goto T, Kim MJ, Takahashi H, Takahashi N, Kawada T.
  • Food intake and thermogenesis in adipose tissue
    Korean J Obesity In press
  • Yeh Y-S, Takahashi N, Egawa K, Takahashi H, Jheng H-F, Kim Y-I, Kawada T, Goto T.
  • Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
    Biochem Biophys Res Commun. in press
  • Li Y, Goto T, Ikutani R, Lin S, Takahashi N, Takahashi H, Jheng H-F, Taniguchi M, Baba K, Murakami S, Kawada T.
  • Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses
    Obesity in press
  • Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M.
  • Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes
    European J Physiol. In press
  • Kobayashi M, Suzuki M, Ohno T, Tsuzuki K, Taniguchi C, Takeishi S, Kawada T, Kim Y-I, Murai A, Horio F.
  • Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12.
    BMC Genetics (2016) 17:73 DOI 10.1186/s12863-016-0385-2
  • Li Y, Goto T, Yamakuni K, Takahashi H, Takahashi N, Jheng J-F, Nomura W, Taniguchi M, Baba K, Murakami S, Kawada T.
  • 4-Hydroxyderricin, as a PPARγ agonist, promotes adipogenesis, adiponectin secretion, and glucose uptake in 3T3-L1 cells
    Lipids in press.
  • Yamamoto T, Li Y, Hanafusa Y, Yeh Y-S, Maruki-Uchida H, Kawakami S, Sai M, Goto T, Ito T, Kawada T.
  • Piceatannol Exhibits Anti-inflammatory Effects on Macrophages Interacting with Adipocytes
    Food Science & Nutrition in press.
  • Nakamura F, Ishida Y, Sawada D, Ashida N, Sugawara T, Sakai M, Goto T, Kawada T, Fujiwara S.
  • Fragmented Lactic Acid Bacterial Cells Activate Peroxisome Proliferator-Activated Receptors and Ameliorate Dyslipidemia in Obese Mice.
    J Agric Food Chem. (2016) 64:2549-2559.
  • Sakamoto T, Nitta T, Maruno K, Yeh YS, Kuwata H, Tomita K, Goto T, Takahashi N, Kawada T.
  • Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 expression in mice
    Am J Physiol. Endocrinology and Metabolism In press
  • Sun W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M.
  • Lack of TRPV2 impaired thermogenesis in mouse brown adipose tissue.
    EMBO Reports In press
  • Kida R, Yoshida H, Murakami M, Shirai M, Hashimoto O, Kawada T, Matsui T, Funaba M.
  • Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.
    Cell Biochem Funct. (2016) 34:34-41.
  • Goto T, Naknukool S, Yoshitake R, Hanafusa Y, Tokiwa S, Li Y, Sakamoto T, Nitta T, Kim MJ, Takahashi N, Yu R, Daiyasu H, Seno S, Matsuda H, Kawada T.
  • Proinflammatory cytokine interleukin-1beta suppresses cold-induced thermogenesis in adipocytes
    Cytokine. (2016) 77:107-114.
  • 河田 照雄
  • 褐色脂肪と中年太り?食品から誘導される体熱産生のしくみ
    実験医学 34巻12月号(2016)
  • 河田 照雄
  • 特定保健用食品と新機能性食品制度
    生物工学 印刷中
  • 後藤剛、高橋春弥、高橋信之、河田照雄
  • PPARα特集「食品成分によるPPARαの活性化」
    The Lipids 印刷中
  • 河田 照雄
  • 「肥満・エネルギー代謝とポリフェノール」
    日本ポリフェノール学会誌 (2016)総説
  • 後藤剛、河田照雄
  • 生活習慣病と栄養 :「生活習慣病と機能性食品 」
    CLINICAL CALCIUM  2016年3月号

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2015年研究業績

    Goto T, Takahashi N, Kawada T.
  • Food Components Modulate Obesity and Energy Metabolism via the Transcriptional Regulation of Lipid-Sensing Nuclear Receptors.
    J Nutr Sci Vitaminol (Tokyo). (2015) 61: S128-130.
  • Kim MJ, Goto T, Yu R, Uchida K, Tominaga M , Kano Y , Takahashi N, Kawada T.
  • Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the 2 sympathetic nervous system
    Scientific Reports (2015) Dec 17; 5:18013.
  • Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A. Lai, Junne-Ming Sung, and Yau-Sheng Tsai.
  • Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
    Disease Models & Mechanisms, (2015) 8, 1311-1321.
  • Kim CS, Kwon Y, Choe SY, Hong SM, Yoo H, Goto T, Kawada T, Choi HS, Joe Y, Chung HT, Yu R.
  • Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1
    Nutr Metab (Lond). 2015 Oct 6;12:33
  • Takahashi H, Kamakari K, Goto T, Hara H, Mohri S, Nakata R, Inoue H, Suzuki H, Shibata D, Takahashi N, Kawada T.
  • 9-oxo-10(E),12(Z),15(Z)-octadecatrienoic acid activates peroxisome proliferator-activated receptor-α in hepatocytes
    Lipids. (2015) 50:1083-1091.
  • Nanthirudjanar T, Furumoto H, Zheng J, Kim YI, Goto T, Takahashi N, Kawada T, Park SB, Hirata A, Kitamura N, Kishino S, Ogawa J, Hirata T, Sugawara T.
  • Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes
    Lipids. (2015) 50:1093-1102.
  • Taketani K, Hoshino S, Uemura T, Goto T, Takahashi N, Tsuge N, Kawada T.
  • An efficient purification method for quantitative determinations of protodioscin, dioscin and diosgenin in plasma of fenugreek-fed mice.
    J. Nutr. Sci. Vitaminol. In press
  • Matsumoto H, Ushimaru S, Matsuda T, Shimada T, Mikuri M, Takahashi H, Takahashi N, Kawada T, Yamazaki T.
  • Is Caffeine Abstention Necessary before Adenosine-Induced Fractional Flow Reserve Measurement?
    J. Amer. Coll. of Cardiol. (2015) 66:1943-1945.
  • Goto T, Kim YI, Furuzono T, Takahashi N, Yamakuni K, Yang HE, Li Y, Ohue R, Nomura W, Sugawara T, Yu R, Kitamura N, Park SB, Kishino S, Ogawa J, Kawada T.
  • 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARgamma and stimulates adipogenesis.
    Biochem Biophys Res Commun. (2015) 459: 597-603.
  • Kim YI, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T.
  • Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages
    Biosci Biotechnol Biochem (2015) 79:82-87.
  • Tu T H, Kim C-S, Nam-Goong I S, Nam C K, Kim YI, Goto T, Kawada T, Park T, Yoon P, Jung H, Ryoo Z Y, Park J W, Choi H-S, Yu R.
  • 4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages
    FEBS J (2015) 282:1468-1480.
  • Takahashi H, Hara H, Goto T, Kamakari K, Wataru N, Mohri S, Takahashi N, Suzuki H, Shibata D, Kawada T.
  • 3-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator- Activated Receptor γ in Adipocytes.
    Lipids (2015) 50:3-12.
  • Takahashi H, Goto T, Yamazaki Y, Kamakari K, Hirata M, Suzuki H, Shibata D, Takahashi N, Kawada T.
  • Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptorα
    J Lipid Res. (2015)56:254-265.
  • Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E.
  • Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation.
    Biochem Biophys Res Commun. (2015);457:23-30.
  • 河田照雄、高橋信之、後藤剛
  • 『食品因子による栄養機能制御』第3章「脂肪・エネルギー代謝とβ-クリプトキサンチン」
    建帛社 東京 (2015)
  • 後藤剛、河田照雄
  • 肥満症の食事療法各論:「抗肥満機能性食品の現状と展望」
    『臨床栄養』第127巻4号 (2015年秋増刊号)

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2014年研究業績

    Le N H, Kim C-S, Park T, Park J H, Sung M-K, Lee D G, Hong S-M, Goto T, Kawada T, Yu R.
  • Quercetin Protects Against Obesity-Induced Skeletal Muscle Inflammation and Atrophy.
    Mediators of Inflammation. (2014);2014:834294.
  • Yoshino S, Kim M, Awa R, Kuwahara H, Kano Y, Kawada T.
  • Kaempferia parviflora extract increases energy consumption through activation of BAT in mice.
    Food Science & Nutrition (2014)2:634-7.
  • Yamamoto T, Takahashi H, Suzuki K, Hirano A, Kamei M, Goto T, Takahashi N, Kawada T.
  • Theobromine Enhances Absorption of Cacao Polyphenol in Rats.
    Biosci Biotechnol Biochem. (2014)78:2059-2063.
  • Hien Tu T-H, Kim C-S, Kang J-H, Nam-Goong I, Nam G, Kim E-S, Kim Y-I, Choi J-I, Kawada T, Goto T, Park T, Choi MS, Yu R.
  • Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters.
    Int J Obesity (2014) 38: 1075-1082.
  • Takahashi H, Kamakari K, Suzuki H, Mohri S, Goto T, Takahashi N, Matsumura Y, Shibata D, Kawada T.
  • Localization of 9- and 13-oxo-octadecadienoic acids in tomato fruit.
    Biosci. Biotechnol. Biochem. (2014)78:1761-1764.
  • Moriwaki S, Murakami H, Takahashi N, UemuraT, Taketani K, HoshinoS, Tsuge N, Goto T, Kawada T.
  • Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.
    Biosci. Biotechnol. Biochem. (2014)78:1231-1236.
  • Nagai H, Kawada T, Goto T, Kusudoh T, Tanaka T, Takahashi N.
  • Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.
    Biosci. Biotechnol. Biochem. (2014)78:296-300.
  • Hirai S, Ohyane C, Kim Y-I, Lin S, Goto T, Takahashi N, Kim C-S, Kang J, Yu R, Kawada T.
  • Involvement of mast cells in adipose tissue fibrosis.
    Am J Physiol. Endocrinology and Metabolism (2014) 306:E247-255.
  • Sakamoto T, Takahashi N, Goto T, Kawada T.
  • Dietary factors evoke thermogenesis in adipose tissues.
    Obesity Research & Clinical Practice (2014)8:e533-539.
  • 河田照雄
  • 肥満と脂肪・エネルギー代謝に関する食品機能学的研究 (平成25年度日本栄養・食糧学会賞受賞)
    日本栄養・食糧学会誌 総説 (2014) 67巻3号
  • 毛利晋輔、河田照雄
  • 脂肪酸の魅力、再発見
    Functional Food (2014)8:114 -116
  • 毛利晋輔、河田照雄
  • トマト由来オキソ脂肪酸:oxo-octadecadienoic acid (oxo-ODA)
    医学のあゆみ 印刷中

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2013年研究業績

    Kimura R, Takahashi N, Lin S, Goto T, Murota K, Nakata R, Inoue H, Kawada T.
  • DHA attenuates postprandial hyperlipidemia via activating PPARalpha in intestinal epithelial cells.
    J Lipid Res. (2013)54:3258-3268.
  • Kimura R, Takahashi N, Goto T, Murota K, Kawada T.
  • Activation of peroxisome proliferator-activated receptor-α (PPARα) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice.
    Obes Res Clin Pract. (2013)7:e353-360.
  • Le N. H, Kim C-S, Tu T. H, Choi H. S, Kim B-S, Kawada T, Goto T, Park T, Park J.H.Y, Yu R.
  • Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation.
    Mediators of Inflammation (2013);2013:865159.
  • Matsuura N, Gamo K, Miyachi H, Iinuma M, Kawada T, Takahashi N, Akao Y, Tosa H.
  • γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ.
    Biosci Biotechnol Biochem. (2013) 77:2430-2435.
  • Takahashi H, Suzuki H, Suda K, Yamazaki Y, Takino A, Kim Y-I, Goto T, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • Long-chain free fatty acid profiling analysis by liquid chromatography - mass spectrometry in mouse treated with peroxisome proliferator-activated receptor α.
    Biosci. Biotechnol. Biochem. (2013) 77(11):2288-93.
  • Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, Nishimori K.
  • Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice.
    Endocrinology (2013) 154:4305-4315.
  • Yoshida H, Kanamori Y, Asano H, Hashimoto O, Murakami M, Kawada T, Matsui T, Funaba M.
  • Regulation of brown adipogenesis by the Tgf-β family: Involvement of Srebp1c in Tgf-β- and Activin-induced inhibition of adipogenesis.
    Biochim Biophys Acta. (2013)10;1830(11):5027-5035.
  • Lin S, Hirai S, Yamaguchi Y, Goto T, Takahashi N, Tani F, Mutoh C, Sakurai T, Murakami S, Yu R, Kawada T.
  • Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.
    Mol Nutr Food Res. (2013) 57:2155-2165.
  • Takahashi N, Yao L, Kim M, Sasako H, Aoyagi M, Shono J, Tsuge N, Goto T, Kawada T.
  • Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice.
    Mol Nutr Food Res. (2013) 57:1295-1299.
  • Sakamoto T, Takahashi N, Sawaragi Y, Naknukool S, Yu R, Goto T, Kawada T.
  • Inflammation induced by RAW macrophages suppresses the UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes.
    Am J Physiol Cell Physiol. (2013) 304:C729-738.
  • Lin S, Hirai S, Goto T, Sakamoto T, Takahashi N, Yano M, Sasaki T, Yu R, Kawada T.
  • Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 MAPK activation
    Mol Nutr Food Res. (2013) 57:1135-1144.
  • Goto T, Kim YI, Takahashi N, Kawada T.
  • Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors. Review
    Mol Nutr Food Res. (2013) 57(1):20-33.
  • Goto T, Mori A, Nagaoka S.
  • Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells.
    Mol Nutr Food Res. (2013) 57:1435-1445.
  • Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T.
  • Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats.
    J Immunotoxicol. (2013) 10: 40-48.
  • 坂本智弥、高橋信之、後藤剛、河田照雄
  • 褐色脂肪組織の生理的役割と機能制御
    細胞工学(2013)Vol.32. No.7, 2-7.
  • 金英一、河田照雄
  • トマトから見出された脂質代謝改善成分oxo-ODA
    医学のあゆみ(2013) 244:1063-1064.
  • 高橋信之、後藤剛、河田照雄
  • リコペンの効果
    内分泌・糖尿病・代謝内科(2013) 36(4):317-322
  • 河田照雄 編著
  • 脂肪の功罪と健康 書籍 2013年 建帛社発行

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2012年研究業績

    Goto T, Takahashi N, Kato S, Kim YI, Kusudo T, Taimatsu A, Egawa K, Kang MS, Hiramatsu T, Sakamoto T, Uemura T, Hirai S, Kobayashi M, Horio F, Kawada T.
  • Bixin Activates PPARα and Improves Obesity-Induced Abnormalities of Carbohydrate and Lipid Metabolism in Mice.
    J Agric Food Chem. (2012) 60(48):11952-8. doi: 10.1021/jf303639f.
  • Le NH, Shin S, Tu TH, Kim CS, Kang JH, Tsuyoshi G, Teruo K, Han SN, Yu R.
  • Diet enriched with korean pine nut oil improves mitochondrial oxidative metabolism in skeletal muscle and brown adipose tissue in diet-induced obesity.
    J Agric Food Chem. (2012) 60(48):11935-41. doi: 10.1021/jf303548k.
  • Tu TH, Kim CS, Goto T, Kawada T, Kim BS, Yu R.
  • 4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages.
    Mediators Inflamm. (2012);2012:972629. doi: 10.1155/2012/972629.
  • Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
  • Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet.
    J Nutr Biochem. (2012) 24: 887-893.
  • Sugiura C, Nishimatsu S, Moriyama T, Ozasa S, Kawada T, Sayama K.
  • Catechins and Caffeine Inhibit Fat Accumulation in Mice through the Improvement of Hepatic Lipid Metabolism.
    J Obes. (2012) 2012:520510.
  • Kuroda M, Mimaki Y, Ohtomo T, Yamada J, Nishiyama T, Mae T, Kishida H, Kawada T.
  • Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK-A(y) mice and identification of the active ingredients.
    J Nat Med. In press
  • Goto T, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Hirai S, Uemura T, Kim YI, Takahashi N, Kawada T.
  • Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.
    J. Nutr. Biochem. (2012) in press.
  • Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K.
  • Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.
    Am. J. Physiol. - Endocrinology and Metabolism (2012) 302: E433-40.
  • Kim Y , Hirai S , Goto T , Ohyane C , Takahashi H , Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice.
    PLoS ONE 7: e31317. doi:10.1371/journal.pone.0031317
  • Lee J-Y*, Takahashi N*, Yasubuchi M, Kim Y-I, Hashizaki H, Kim M-J, Sakamoto T,Goto T, Kawada T.
  • Triiodothyronine Induces UCP1 Expression and Mitochondrial Biogenesis in Human Adipocytes.
    Am. J. Physiol. - Cell Physiology (2012) 302:C463-72. (* equal contributions)
  • 金英一、後藤剛、木村梨乃、高橋信之、河田照雄
  • 食品と肥満;核内受容体リガンドによる代謝制御
    カレントテラピー (2012) 30, 531-535.
  • 河田照雄、坂本智弥
  • 褐色脂肪:脂肪燃焼と食品機能
    週刊医学のあゆみ (2012) 242巻12号 942-946.

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2011年研究業績

    Goto T, Takahashi N, Funakoshi K, Kim Y-I, Teraminami A, Uemura T, Hirai S, Lee J-Y, Makishima M, Nakata R, Inoue H, Senju H, Matsunaga M, Horio F, Kawada T.
  • Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.
    Am. J. Physiol. - Endocrinology and Metabolism (2011) 301: E1022-32.
  • Takahashi N, Senda M, Lin S, Goto T, Yano M, Sasaki T, Murakami S, Kawada T.
  • Auraptene regulates gene expression involved in lipid metabolism through PPAR-alpha activation in diabetic obese mice.
    Mol Nutr & Food Res. (2011) 58:1791-1797.
  • Goto T, Nagai H, Egawa K, Kim Y-I, Kato S, Taimatsu A, Sakamoto T, Hirai S, Ebisu S, Hohsaka T, Miyagawa H, Murakami S, Takahashi N, Kawada T.
  • Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARgamma agonist.
    Biochem J. (2011) 438: 111-119.
  • Matsumura T, Kinoshita H, Ishii N, Fukuda K, Motoshima H, Senokuchi T, Taketa K, Kawasaki S, Nishimaki-Mogami T, Kawada T, Nishikawa T, Araki E.
  • Telmisartan Exerts Antiatherosclerotic Effects by Activating Peroxisome Proliferator-Activated Receptor-gamma in Macrophages.
    Arterioscler Thromb Vasc Biol. (2011) 31: 1268-75.
  • Kim CS, Kim JG, Lee B-J, Choi M-S, Choi H-S, Kawada T, Lee K-U, Yu R.
  • Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders.
    Diabetes (2011) 60:3159-68.
  • Ikeda R, Yanagisawa M, Takahasshi N, Kawada T, Kumazawa S, Yamaotsu N, Nakagome I, Hirono S and Tsuda T.
  • Brazilian propolis-derived components inhibit TNF-alpha-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
    Biochim. Biophys. Acta. (2011) 1810: 695-703.
  • Takahashi H, Kim IL, Hirai S, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • Comparative and stability analyses of 9- and 13-oxo-octadecadienoic acid in various species of tomato.
    Biosci. Biotechnol. Biochem. (2011) 75: 1621-4.
  • Kim HJ, Kim HM, Kim CS, Jeong CS, Choi HS, Kawada T, Kim BS, Yu R.
  • HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance.
    FEBS Lett. (2011) 585:2285-2290.
  • Kang JH, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R
  • Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice.
    J Med Food. (2011) 14: 310-315.
  • Kimura R, Takahashi N, Murota K, Yamada Y, Kanzaki N, Murakami Y, Goto T, Kawada T.
  • Activation of peroxisome proliferator-activated receptors induces intestinal fatty acid-oxidation to suppress lipid absorption.
    Biochem. Biophys. Res. Commun. (2011) 410: 1-6.
  • Nagai H, Goto T, Takahashi N, Deyashiki Y, Esaka Y, Kawada T.
  • A method for simultaneous determination of 3T3-L1 adipocyte metabolites by liquid chromatography/mass spectrometry using a 13[C]-stable isotopes.
    Biosci. Biotechnol. Biochem. (2011) 75: 1485-9.
  • Sakamoto T*, Yamaguchi Y*, Goto T, Takahashi N, Kawada T.
  • An in vitro analysis system using a fluorescence protein reporter for evaluating anti-inflammatory effects in macrophages.
    Biosci. Biotechnol. Biochem. (2011) 75: 1582-7. (* equal contributions)
  • Takahashi N*, Yao R*, Kang MS*, Senda M, Nishimura K, Hirai S, Yu R, Goto T, Ezaki Y, Kawada T.
  • Dehydroabietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) to regulate gene expression involved in adipogenesis of 3T3-L1 adipocytes.
    BioFactors (2011) 37: 309-14. (* equal contributions)
  • Lee JY, Hashizaki H, Goto T, Sakamoto T, Takahashi N, Kawada T.
  • Activation of PPAR-alpha enhances fatty acid oxidation in human adipocytes.
    Biochem. Biophys. Res. Commun. (2011) 407: 818-822.
  • Goto T, Lee J-Y, Teraminami A, Kim Y-I, Hirai S, Uemura T, Inoue H, Takahashi N, Kawada T.
  • Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes.
    J Lipid Res. (2011) 52: 873-884.
  • Nagai H, Ebisu S, Abe R, Goto T, Takahashi N, Hohsaka T, Kawada T.
  • Development of a novel PPARgamma ligand screening system using pinpoint fluorescence-probed protein.
    Biosci. Biotechnol. Biochem. (2011) 75: 337-341.
  • Uemura T, Goto T, Kang M-S, Mizoguchi N, Hirai S, Lee, J-Y, Nakano Y, Shono J, Hoshino S, Taketani K, Tsuge N, Narukami T, Makishima M, Takahashi N, Kawada T.
  • Diosgenin, the Main Aglycon of Fenugreek, Inhibits LXRα Activity in HepG2 cells and Decreases Plasma and Hepatic Triglycerides in Obese, Diabetic Mice.
    J. Nutr. (2011) 141: 17-23.
  • Kim Y-I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent peroxisome proliferator-activated receptor α agonist to decrease triglyceride accumulation in mouse primary hepatocytes.
    Mol. Nutr. Food Res. (2011) 55: 585-593.
  • 河田照雄
  • カプサイシンの機能性を学ぼう 
    月刊「食生活」2011年7月号
  • 河田照雄
  • 巻頭言:脂肪細胞 ふるきを尋ね、あたらしきを観る
    肥満研究 2011年1号
  • 後藤剛、李周容、高橋信之、河田照雄
  • メタボリックシンドロームー基礎・臨床の最新知見- 第2版 メタボリックシンドローム発症基盤としての脂肪細胞機能異常:脂肪細胞のライフサイクルとその制御因子
    日本臨牀 (印刷中)
  • 河田照雄、大山夏奈、高橋信之
  • β-クリプトキサンチンー糖・脂質代謝改善作用
    Functional Food (2011) 4: 294-299
  • 河田照雄、高橋信之、後藤剛
  • 褐色脂肪研究の新展開:体熱産生・褐色脂肪機能と食品因子
    肥満研究 (2011) 17: 96-101
  • 河田照雄
  • 褐色脂肪・UCP1を活性化させる脂肪酸はありますか?
    肥満と糖尿病 (2011) 10: 印刷中

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2010年研究業績

    Kang J-H, Goto T, Han I-S, Kim C-S, Kawada T, Kim Y-M, Yu R.
  • Dietary Capsaicin reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice fed a High-fat Diet.
    Obesity (2010) 18: 780-787.
  • Kim CS, Tu TH, Kawada T, Kim BS, Yu R.
  • The Immune Signaling Molecule 4-1BB Stimulation Reduces Adiposity, Insulin Resistance, and Hepatosteatosis in Obese Mice.
    Endocrinology. (2010) 151: 4725-4735.
  • Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E.
  • Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.
    Arterioscler Thromb Vasc Biol. (2010) 30: 1598-15605.
  • Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, Taketani K, Nakano Y, Shono J, Hoshino S, Tsuge N, Narukami T, Takahashi N, Kawada T.
  • Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
    Mol. Nutr. Food Res. (2010) 54: 1596-1608.
  • Inoue, H., Takahashi, N., Okada, Y. and Konishi, M.
  • Volume-sensitive outwardly rectifying chloride channel in white adipocytes. Am.
    J. Physiol.: Cell Physiol. (2010) 298: C900-C909.
  • Goto T, Takahashi N, Hirai S, Kawada T.
  • Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism.
    PPAR Res. (2010) 2010: 483958.
  • Hirai S, Takahashi N, Goto T, Lin S, Uemura T, Yu R, Kawada T.
  • Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.
    Mediators Inflamm. (2010) 2010: 367838.
  • Fujitani Y, Aritake K, Kanaoka Y, Goto T, Takahashi N, Fujimori K, Kawada T.
  • Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.
    FEBS J. (2010) 277: 410-419.
  • Hirai, S.*, Uemura, T.*, Mizoguchi, N., Lee, J. Y., Taketani, K., Nakano,Y., Hoshino, S., Tsuge, N., Narukami, T., Yu, R., Takahashi, N. and Kawada,T.
  • Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages.
    Mol. Nutr. Food Res. (2010) 54: 1-8. (* equal contributions)
  • 後藤剛、李周容、寺南亜紀、高橋信之、河田照雄
  • 肥満症(第2版):栄養素によるエネルギー代謝調節 『脂肪細胞での代謝調節』
    日本臨牀 増刊号 (2010) 156-161.
  • 河田照雄
  • 巻頭言:脂肪細胞讃歌
    The Lipid 2010年1月号
  • 高橋信之、河田照雄
  • マッキー生化学(第4版)第16章「代謝の統合的理解」翻訳
    化学同人(2010)

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2009年研究業績

    Takahashi N*, Goto T*, Taimatsu A, Egawa K, Katoh S, Kusudo T, Sakamoto T, Ohyane C, Lee J.Y., Kim Y.I., Uemura T, Hirai S, and Kawada, T.
  • Bixin regulates gene expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPAR-gamma activation.
    Biochem. Biophys. Res. Commun. (2009) 390: 1372-1376. (* equal contributions)
  • Ando C*, Takahashi N*, Hirai S*, Lee J.Y., Goto T, Yu R, and Kawada T.
  • Luteolin, a food-derived flavonoid, inhibits adipocyte-dependent activation of macrophages in adipose tissues.
    FEBS Lett. (2009) 583: 3649-3654. (* equal contributions)
  • Kang M.S., Hirai S, Goto T, Kuroyanagi K, Kim I.Y., Ohyama K, Uemura T, Lee J.Y., Sakamoto T, Ezaki Y, Yu R, Takahashi N, and Kawada T.
  • Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation of mouse adipose tissues.
    BioFactors (2009) 35: 442-448.
  • Iwasaki K, Kamauchi S, Wadahama H, Ishimoto M, Kawada T, Urade R.
  • Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs.
    FEBS J. (2009) 276: 4130-4141.
  • Takahashi N, Goto T, Hirai S, Uemura T, and Kawada T.
  • Genome science of lipid metabolism and obesity.
    in: FOOD FACTORS for HEALTH PROMOTION (Dr. T. Yoshikawa, Kyoto, Japan), Forum Nutri. (2009) 61: 25-38.
  • Goto T, Hirai S, Yu R, Takahashi N, and Kawada T.
  • Obesity and Nuclear Receptors : Effective Genomic Strategies in Functional Foods.
    in: NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds) (2009) 47-58. WILEY-BLACK WELL
  • Goto T, Hirai S, Yu R, Takahashi N, and Kawada T.
  • Isoprenols : Effective Genomic Strategies in Functional Foods.
    in: NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds) (2009) 301-310. WILEY-BLACK WELL
  • Lee HS, Park JH, Kang JH, Kawada T, Yu R, Han IS
  • Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice.
    Cytokine. (2009) 46: 160-165.
  • Mochizuki Y, Maebuchi M, Kohno M, Hirotsuka M, Wadahama H, Moriyama T, Kawada T, Urade R.
  • Changes in lipid metabolism by soy beta-conglycinin-derived peptides in HepG2 cells.
    J Agric Food Chem. (2009) 57: 1473-1480.
  • 高橋信之、大山夏奈、千田真里、西村加奈子、河田照雄
  • カロテノイドの科学と最新応用技術 第11章「カンキツ由来カロテノイドの機能性」
    シーエムシー出版(2009)

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2008年研究業績

    Taketa K, Matumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T,Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E.
  • Ox-LDL activates PPARalpha and PPARgamma through MAPK-dependent COX-2 expression in macrophages.
    J Biol Chem. (2008) 283: 9852-9862.
  • Takahashi N, Kang M-S, Kuroyanagi K, Goto T, Hirai S, Ohyama K, Lee J-Y, Yu R, Yano M, Sasaki T, Murakami S, Kawada T.
  • Auraptene, a citrus fruit compound, regulates gene expression as a PPAR-alpha agonist in HepG2 hepatocytes.
    BioFactors. (2008) 33: 25-32.
  • Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
  • Oleuropein, a phenolic compound in etra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol (Tokyo). (2008) 54: 363-307.
  • Isa Y, Miyakawa Y, Yanagisawa M, Goto T, Kang MS, Kawada T, Morimitsu Y, Kubota K, Tsuda T.
  • 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanism in 3T3-L1 adipocytes.
    Biochem Biophys Res Commun. (2008) 373: 429-434.
  • Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K.
  • Oxytocin receptor-deficient mice developed late onset obesity.
    Neuro Report. (2008) 19: 951-955.
  • Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T.
  • Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in Macrophages and adipocytes to regulate inflammation.
    Biochem Biophys Res Commun. (2008) 369: 333-338.
  • Kawada T, Goto T, Hirai S, Kang M-S, Uemura T, Yu R, Takahashi N.
  • Dietary regulation of nuclear receptors in obesity-related metabolic syndrome.
    Asia Pac J Clin Nutr. (2008) 17(Suppl): 126-130.
  • Kuroyanagi K, Kang MS, Goto T, Hirai S, Ohyama K, Kusudo T, Yu R, Yano M, Sasaki T, Takahashi N, Kawada T.
  • Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocyte.
    Biochem Biophys Res Commun. (2008) 366: 219-225.
  • Kim C-S, Lee SC, Kim BS, Kim YM, Kawada T, Kwon B-S Yu R.
  • Visceral fat accumlation causes the atrophy of mesenteric lymph nodes in obese mice fed a high-fat diet.
    Obesity. (2008) 16: 1261-1269.
  • Kang JH, Han IH, Sung MK, Yoo H, Kim YG, Kim JS, Kawada T, Yu R.
  • Soybean saponin inhibits tumor cell metastasis by modulating expression of MMP-2, MMP-9 and TIMP-2.
    Cancer Lett. (2008) 261: 84-92.
  • Wadahama H, Kamauchi S, Nakamoto Y, Nishizawa K, Ishimoto M, Kawada T, Urade R.
  • A novel plant protein disulfide isomerase family homologous to animal P5: molecular cloning and characterization as a functional protein for folding of soybean seed storage protein.
    FEBS J. (2008) 275: 399-410.
  • 河田 照雄、後藤 剛、平井 静、高橋 信之
  • 脂質代謝と生活習慣病・メタボリックシンドローム
    生物工学 (2008) 86: 469-487.
  • 平井 静、後藤 剛、柳 梨娜、高橋 信之、河田 照雄
  • 肥満と脂肪エネルギー代謝:肥満・メタボリックシンドロームと食品機能
    建帛社 (2008)
  • 河田 照雄
  • 栄養学研究の最前線:病態栄養分野の進歩と課題
    建帛社 (2008)
  • 河田 照雄
  • 食品機能性の科学:辛味成分およびフィトケミカル
    産業技術サービスセンター (2008)
  • 河田 照雄
  • 肥満・メタボッリックシンドロームと食品
    ネスレ栄養科学レビュー(http://www.nestle.co.jp/science/review/review0712.htm

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2007年研究業績

    Kasahara Y, Takayanagi Y, Kawada T, Itoi K, Nishimori K.
    Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure.
    Biosci Biotechnol Biochem. (2007) 71: 3122-3126. Sakane N, Kotani K, Hioki C, Yoshida T, Kawada T.
  • Up-regulation of muscle uncoupling protein 3 gene expression by calcium channel blocker, Benidipine Hydrochloride in rats.
    Endocr. J. (2007) 54: 771-775.
  • Hirai S, Kim Y-I, Goto T, Kang M-S, Yoshimura M, Obata A, Yu R, Kawada T.
  • Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages.
    Life Sci. (2007) 81: 1272-1279.
  • Kang J-H, Kim C-S,Han I-S, Kawada T, Yu R.
  • Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages.
    FEBS Letters (2007) 581: 4389-439
  • Yano Y, Matsumura T, Senokuchi T, Ishii N, Motoshima H, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Sakai M, Kawada T, Nishikawa T, Araki E.
  • Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: Impact of the suppression of nuclear translocation of ERK1/2.
    Atherosclerosis (2007) 191: 22-32.
  • Yano Y, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada K, Brownlee M, Nishikawa T, Araki E.
  • Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependet Cyclooxygenase-2 Expression in Macrophages.
    Circ. Res. (2007) 100: 1442-1451.
  • Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
  • Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue, and enhances noradrenaline and adrenaline secretion in rats.
    J Nutr Biochem. (2007) 18: 685-692.
  • Woo H-M , Kang J-H , Kim C-S, Kawada T, Yoo H, Sung M-K, Yu R.
  • Spices-derived active components inhibit obesity-induced inflammatory responses by modulating the behavior of adipose tissue macrophages and the release of MCP-1 from adipocytes.
    Life Sci. (2007) 80: 926-931.
  • Kawachi H, Moriya NH, Korai T, Tanaka S, Watanabe M, Matsui T, Kawada T, Yano H.
  • Nitric oxide suppresses preadipocyte differentiation in 3T3-L1 culture.
    Mol. Cell. Biochem. (2007) 300: 61-67.
  • Kondoh Y, Teruo Kawada, Reiko Urade.
  • Activation of caspase 3 in HepG2 cells by elaidic acid (t18:1) Biochim.
    Biophys Acta (2007) 1771: 500-505.
  • Urade R
  • Cellular response to unfolded proteins in the endoplasmic reticulum of plants.
    FEBS Journal (2007) 102: 225-231.
  • Wadahama H, Kamauchi S, Ishimoto M, Kawada T and Urade R
  • Protein disulfide isomerase family proteins involved in soybean protein biogenesis.
    FEBS Journal (2007) 274: 687-703.
  • Ukai T and Urade R
  • Cooperation of phosphatidylcholine with endogenous lipids of wheat flour for an increase in dough volume.
    Food Chemistry (2007) 102: 225-231
  • 植村 卓、後藤 剛、河田 照雄
  • 抗肥満食品・素材の開発と応用展開;抗肥満のメカニズム
    シーエムシー出版 (2007)
  • 後藤 剛、植村 卓、村上 陽子、河田 照雄
  • メタボリック症候群と栄養:メタボリック症候群と食品機能ー糖尿病関連
    幸書房 (2007) 175-187.
  • 平井 静、楠堂 達也、向井 佐輝子、河田 照雄
  • 培養脂肪細胞の分化プロトコール、「糖尿病カレントライブラリー」
    文光堂 (2007) 276-279.
  • Meet the Professor-13 Dr. Christian Dani
  • ヒト脂肪組織由来多能性幹細胞(hMADS)の確立とその応用研究,および脂肪細胞分化と発達のキー分子,FGF,ERKの機構探索
    Adiposcience (2007) 4: 88-95.

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