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  • 2019
  • 2018
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  • 2007

2019”NŒ¤‹†‹ÆÑ

    Suzuki M, Chen HJ, Tomonaga S, Hashimoto O, Kawada T, Matsui T, Funaba M.
  • Chronic retinoic acid treatment induces differentiation and changes in the metabolite levels of brown (pre)adipocytes.
    Cell Biochemistry and Function. in press
  • Kawarasaki S, Kuwata H, Sawazaki H, Sakamoto T, Nitta T, Kim CS, Jheng HF, Takahashi H, Nomura W, Ara T, Takahashi N, Tomita K, Yu R, Kawada T, Goto T.
  • A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression.
    FEBS letters. in press
  • Ng SP, Nomura W, Mohri S, Takahashi H, Jheng HF, Ara T, Nagai H, Ito T, Kawada T, Goto T.
  • Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in ƒÀ-adrenergic receptor expression in adipocytes.
    Biosci Biotechnol Biochem. in press
  • Kiriyama K, Goto T, Yamamoto H, Ara T, Takahashi H, Jheng HF, Nomura W, Inoue H, Nakata R, Kawada T.
  • Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice.
    Journal of Functional Foods. 2019; 54: 529-535.
  • Yuliana A, Daijo A, Jheng HF, Kwon J, Nomura W, Takahashi H, Ara T, KawadaT, Goto T.
  • Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor ƒÁ Binding Activity in Mice Beige Adipocytes.
    Int J Mol Sci. 2019 Jan 11;20(2). pii: E274. doi: 10.3390/ijms20020274.
  • Œã“¡„E‹àûa’qEìŒ´è‘ŽqE‚‹´t–íE‰Í“cÆ—YD
  • H‰a—R—ˆ’°“à×‹Û‘ãŽÓŽY•¨‚É‚æ‚銌FŽ‰–b‘gD‹@”\’²ßD
    ƒIƒŒƒIƒTƒCƒGƒ“ƒX‘æ19Šª‘æ4† (2019”N)

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
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  • 2007

2018”NŒ¤‹†‹ÆÑ

    Aoki Y, Sugawara T, Yanagihara S, Takahashi H, Nomura W, Jheng HF, Ara T, Goto T, Kawada T, Sawada D.
  • 10-Hydroxyoctadecanoic acid from Lactobacillus amylovorus CP1563 activates PPARƒ¿ and improves dyslipidemia.
    Pharmacometrics. 2018; 95: 73-82.
  • Shibata M, Hirotsuka M, Mizutani Y, Takahashi H, Kawada T, Matsumiya K, Hayashi Y, Matsumura Y.
  • Thermal Treatment of Soybean Seeds can Improve the Quality of Soymilk by Enhancing the Extraction Efficiency of "Kokumi" Taste Components.
    Food Science And Technology Research. 2018; 24(6) 1111-1119.
  • Takahashi S, Waki N, Mohri S, Takahashi H, Ara T, Aizawa K, Suganuma H, Kawada T, Goto T.
  • Apo-12'-lycopenal, a Lycopene Metabolite, Promotes Adipocyte Differentiation via Peroxisome Proliferator-activated Receptor Gamma Activation.
    J Agric Food Chem. 2018 Dec 19;66(50):13152-13161. doi: 10.1021/acs.jafc.8b04736.
  • Yeh YS, Jheng HF, Iwase M, Kim M, Mohri S, Kwon J, Kawarasaki S, Li Y, Takahashi H, Ara T, Nomura W, Kawada T, Goto T.
  • The Mevalonate Pathway Is Indispensable for Adipocyte Survival.
    iScience. 2018 Oct 21;9:175-191. doi: 10.1016/j.isci.2018.10.019. [Epub ahead of print]
  • Takeda K, Sawazaki H, Takahashi H, Yeh YS, Jheng HF, Nomura W, Ara T, Takahashi N, Seno S, Osato N, Matsuda H, Kawada T, Goto T.
  • The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice.
    FEBS Open Bio. 2018 Sep 19;8(11):1782-1793. doi: 10.1002/2211-5463.12498. eCollection 2018 Nov.
  • Suzuki M, Murakami M, Shirai M, Hashimoto O, Kawada T, Matsui T, Funaba M.
  • Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes.
    Cell Biochem Funct. 2018 Nov 8. doi: 10.1002/cbf.3366. [Epub ahead of print]
  • Yuliana A, Jheng HF, Kawarasaki S, Nomura W, Takahashi H, Ara T, Kawada T, Goto T.
  • ƒÀ-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte.
    Int J Mol Sci. 2018 Aug 17;19(8). pii: E2436. doi: 10.3390/ijms19082436.
  • Kim J, Kwon YH, Kim CS, Tu TH, Kim BS, Joe Y, Chung HT, Goto T, Kawada T, Park T, Choi MS, Kim MS, Yu R.
  • The involvement of 4-1BB/4-1BBL signaling in glial cell-mediated hypothalamic inflammation in obesity.
    FEBS Open Bio. 2018 Apr 19;8(5):843-853. doi: 10.1002/2211-5463.12426.
  • Kawada T.
  • Food-derived regulatory factors against obesity and metabolic syndrome.
    Biosci Biotechnol Biochem. 2018 Apr; 82(4): 547-553.
  • Zheng J, Li Z, Manabe Y, Kim M, Goto T, Kawada T, Sugawara T.
  • Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor ƒ¿ Activity.
    Lipids.Jan; 53(1): 41-52.
  • An JY, Jheng HF, Nagai H, Sanada K, Takahashi H, Iwase M, Watanabe N, Kim YI, Teraminami A, Takahashi N, Nakata R, Inoue H, Seno S, Matsuda H, Kawada T, Goto T
  • A phytol-enriched diet activates PPARƒ¿ in the liver and brown adipose tissue to ameliorate obesity-induced metabolic abnormalities.
    Mol Nutr Food Res. 2018 Mar; 62(6): e1700688.
  • Shibata M, Hirotsuka M, Mizutani Y, Takahashi H, Kawada T, Matsumiya K, Hayashi Y, Matsumura Y.
  • Diversity of ƒÁ-glutamyl peptides and oligosaccharides, the "kokumi" taste enhancers, in seeds from soybean mini core collections.
    Biosci Biotechnol Biochem. 2018 Mar; 82(3): 507-514.
  • Kida R, Noguchi T, Murakami M, Hashimoto O, Kawada T, Matsui T, Funaba M.
  • Supra-pharmacological concentration of capsaicin stimulates brown adipogenesis through induction of endoplasmic reticulum stress.
    Sci Rep. 2018 Jan 16;8(1):845. doi: 10.1038/s41598-018-19223-2.
  • Mohri S, Takahashi H, Sakai M, Takahashi S, Waki N, Aizawa K, Sugamura H, Ara T. Matsumura Y, Shibata D, Goto T, Kawada T.
  • Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions.
    PLOS ONE. 2018 Jan 12;13(1):e0191203
  • Ohue-Kitano R, Yasuoka Y, Goto T, Kitamura N, Park S-B, Kishino S, Kimura I, Kasubuchi M, Takahashi H, Li Y, Yeh Y-S, Jheng H-F, Iwase M, Tanaka M, Masuda S, Inoue T, Yamakage H, Kusakabe T, Tani T, Shimatsu A, Ogawa J, Satoh-Asahara N, Kawada T.
  • Alpha-linolenic acid-derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40.
    FASEB J 2018 Jan;32(1):304-318. Dec10.1096/fj.201700273R.
  • ‚‹´M”VA‰Í“cÆ—Y.
  • ƒ}ƒbƒL[¶‰»Šwi‘æ6”Łj‘æ16Íu‘ãŽÓ‚Ì“‡“I—‰ðv–|–ó.
    ‰»Šw“¯l. 2018”N.

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
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  • 2007

2017”NŒ¤‹†‹ÆÑ

    Takahashi H, Sanada K, Nagai H, Li Y, Aoki Y, Ara T, Seno S, Matsuda H, Yu R, Kawada T, Goto T.
  • Over-expression of PPARƒ¿ in obese mice adipose tissue improves insulin sensitivity
    Biochem Biophys Res Commun.2017 Nov4; 493(1): 108-114
  • Shibata M, Hirotsuka M, Mizutani Y, Takahashi H, Kawada T, Matsumiya K, Hayashi Y, Matsumura Y.
  • Isolation and characterization of key contributors to the "kokumi" taste in soybean seeds.
    Biosci Biotechnol Biochem. 2017 Nov; 81(11):2168-2177. doi:10.1080/09168451.2017.1372179.
  • Nakato J, Ho YY, Omae R, Mizushige T, Uchida K, Tominaga M, Kim M, Goto T, Takahashi N, Kawada T, Akiduki S, Kanamoto R, Ohinata K.
  • L-Ornithine and L-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1.
    Mol Nutr Food Res 2017 Nov; 61(11)
  • Kim M, Furuzono T, Yamakuni K, Li Y, KimY-I, Takahashi H, Ohue-Kitano R, Jheng H-F, Takahashi N, Kano Y, Yu R, Kishino S, Ogawa J, Uchida K, Yamazaki J, Tominaga M, Kawada T, Goto T.
  • 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1.
    FASEB J 2017 Nov; 31(11):5036-5048
  • Yang J, Kim CS, Tu TH, Kim MS, Goto T, Kawada T, Choi MS, Park T, Sung MK, Yun JW, Choe SY, Lee JH, Joe Y, Choi HS, Back SH, Chung HT, Yu R.
  • Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction.
    Nutrients 2017 Jun 23;9(7). pii: E650.
  • Iwase M, Yamamoto T, Nishimura K, Takahashi H, Mohri S, Li Y, Jheng HF, Nomura W, Takahashi N, Kim CS, Yu R, Taniguchi M, Baba K, Murakami S, Kawada T, Goto T.
  • Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARƒÁ Activation
    Lipids 52: 657-664 (2017)
  • Kwon YH, Kim J, Kim CS, Tu TH, Kim MS, Suk K, Kim DH, Lee BJ, Choi HS, Park T, Choi MS, Goto T, Kawada T, Ha TY, Yu R.
  • Hypothalamic lipid-laden astrocytes induce microglia migration and activation
    FEBS Letters 591:1742-1751 (2017)
  • Yang H-E, Li Y, Nishimura A, Jheng H-F, Yuliana A, Kitano-Ohue R, Nomura W, Takahashi N, Kim C-S, Yu R, Kitamura N, Park S-B, Kishino S, Ogawa J, Kawada T, Goto T.
  • Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes
    Mol Nutr Food Res 2017 Oct; 61(10)
  • Goto T, Hirata M, Aoki Y, Iwase M, Takahashi H, Kim M, Li Y, Jheng H-F, Nomura W, Takahashi N, Kim C-S, Yu R, Seno S, Matsuda H , Aizawa-Abe M, Ebihara K, Itoh N, Kawada T.
  • The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-ƒ¿ agonist-induced amelioration of metabolic disorders in obese mice
    J Biol Chem. 2017 Jun 2;292(22):9175-9190.
  • Yu R, Le N H, Kim C-S ,Tu T H, Kim B-S, Park T, ParK H Y, Goto T, Kawada T, Ha T-Y.
  • Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle
    J Inflamm (Lond). 2017 May 11;14:9. doi: 10.1186/s12950-017-0156-5.
  • Oguri Y, Fujita Y, Abudukadier A, Ohashi A, Goto T, Furuta F, Obara A, Fukushima T, Matsuo N, Kim M, Hosokawa M, Kawada T, Hasegawa H, Inagaki N.
  • Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism
    JCI Insight. 2017 May 4;2(9). pii: 91981. doi: 10.1172/jci.insight.91981.
  • Jheng H-F, Hirotsuka M, Goto T, Shibata M, Matsumura Y, Kawada T.
  • Dietary Low-Fat Soy Milk Powder Retards Diabetic Nephropathy Progression via Inhibition of Renal Fibrosis and Renal Inflammation
    Mol Nutr Food Res 2017 Mar,61(3) doi:10. 1002/mnfr.201600461.Equb 2016 Nov 29.

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
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  • 2009
  • 2008
  • 2007

2016”NŒ¤‹†‹ÆÑ

    Takahashi H, Chi H-Y, Mohri S, Kamakari K, Nakata K, Ochijo N, Nakata R, Inoue H, Goto T, Kawada T.
  • Rice Koji Extract Enhances Lipid Metabolism through Proliferator- Activated Receptor Alpha (PPARƒ¿) Activation in Mouse Liver
    J Agric Food Chem. 64: 8848-8856 (2016)
  • Oi-Kano Y, Iwasaki Y, Nakamura T, Watanabe T, Goto T, KawadaT, Watanabe K, Iwai K.
  • Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating ƒÀ-adrenergic signaling
    J Nutr Biochem 40: 209-218 (2016)
  • Asano H, Kida R, Muto K, Nara TY, Kato K, Hashimoto O, Kawada T, Matsui T, Funaba M.
  • Modulation of brown adipocyte activity by milk by-products: Stimulation of brown adipogenesis by buttermilk.
    Cell Biochem Funct. 34: 647-656 (2016)
  • Goto T, Kim MJ, Takahashi H, Takahashi N, Kawada T.
  • Food intake and thermogenesis in adipose tissue
    Korean J Obesity 25:109-114(2016)
  • Yeh Y-S, Takahashi N, Egawa K, Takahashi H, Jheng H-F, Kim Y-I, Kawada T, Goto T.
  • Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
    Biochem Biophys Res Commun. 478:1317-1322(2016)
  • Li Y, Goto T, Ikutani R, Lin S, Takahashi N, Takahashi H, Jheng H-F, Taniguchi M, Baba K, Murakami S, Kawada T.
  • Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses
    Obesity 24:2351-2360(2016)
  • Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M.
  • Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes
    European J Physiol. 468:1527-1540(2016)
  • Kobayashi M, Suzuki M, Ohno T, Tsuzuki K, Taniguchi C, Takeishi S, Kawada T, Kim Y-I, Murai A, Horio F.
  • Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12.
    BMC Genetics (2016) 17:73 DOI 10.1186/s12863-016-0385-2
  • Li Y, Goto T, Yamakuni K, Takahashi H, Takahashi N, Jheng J-F, Nomura W, Taniguchi M, Baba K, Murakami S, Kawada T.
  • 4-Hydroxyderricin, as a PPARƒÁ agonist, promotes adipogenesis, adiponectin secretion, and glucose uptake in 3T3-L1 cells
    Lipids 51:787-795(2016)
  • Yamamoto T, Li Y, Hanafusa Y, Yeh Y-S, Maruki-Uchida H, Kawakami S, Sai M, Goto T, Ito T, Kawada T.
  • Piceatannol Exhibits Anti-inflammatory Effects on Macrophages Interacting with Adipocytes
    Food Science & Nutrition@5:76-85(2016)
  • Nakamura F, Ishida Y, Sawada D, Ashida N, Sugawara T, Sakai M, Goto T, Kawada T, Fujiwara S.
  • Fragmented Lactic Acid Bacterial Cells Activate Peroxisome Proliferator-Activated Receptors and Ameliorate Dyslipidemia in Obese Mice.
    J Agric Food Chem. (2016) 64:2549-2559.
  • Sakamoto T, Nitta T, Maruno K, Yeh YS, Kuwata H, Tomita K, Goto T, Takahashi N, Kawada T.
  • Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 expression in mice
    Am J Physiol. Endocrinology and Metabolism 310:E676-E687(2016)
  • Sun@W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M.
  • Lack of TRPV2 impaired thermogenesis in mouse brown adipose tissue.
    EMBO Reports 17:383-399(2016)
  • Kida R, Yoshida H, Murakami M, Shirai M, Hashimoto O, Kawada T, Matsui T, Funaba M.
  • Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.
    Cell Biochem Funct. (2016) 34:34-41.
  • Goto T, Naknukool S, Yoshitake R, Hanafusa Y, Tokiwa S, Li Y, Sakamoto T, Nitta T, Kim MJ, Takahashi N, Yu R, Daiyasu H, Seno S, Matsuda H, Kawada T.
  • Proinflammatory cytokine interleukin-1beta suppresses cold-induced thermogenesis in adipocytes
    Cytokine. (2016) 77:107-114.
  • …–ì—Y‘¾A£”ö–ΐlA“n粐¾—·A’|’†—vˆêA•½¼‘ñ˜YAŒã“¡„A‰Í“cÆ—YA¼“cG—Y
  • Deep learning‚ð—p‚¢‚½Ž‰–b‘gD‰æ‘œ‚É‚¨‚¯‚é×–E‚Ì”FŽ¯
    î•ñˆ—Šw‰ïŒ¤‹†•ñ vol.2016-MPS-107 No.10: 1-6 (2016)@
  • ‰Í“c@Æ—Y
  • Ž‰–b‚ð–¡•û‚É‚·‚é‰ÈŠw`H‚Ì‹@”\«‚©‚ç‚ÌŽæ‘g‚݁`
    H•i‰ÁH‹ZpF“ú–{H•i‹@‰ïŒ¤‹†‰ïŽ@36:138-142(2016)@
  • ‰Í“c@Æ—Y
  • ŠŒFŽ‰–b‚Æ’†”N‘¾‚è?H•i‚©‚ç—U“±‚³‚ê‚é‘Ì”MŽY¶‚Ì‚µ‚­‚Ý
    ŽÀŒ±ˆãŠw@34Šª12ŒŽ†i2016j
  • ‰Í“c@Æ—Y
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    ¶•¨HŠw@ˆóü’†
  • Œã“¡„A‚‹´t–íA‚‹´M”VA‰Í“cÆ—Y
  • PPARƒ¿“ÁWuH•i¬•ª‚É‚æ‚éPPARƒ¿‚ÌŠˆ«‰»v
    The Lipids@ˆóü’†
  • ‰Í“c@Æ—Y
  • u”ì–žEƒGƒlƒ‹ƒM[‘ãŽÓ‚ƃ|ƒŠƒtƒFƒm[ƒ‹v
    “ú–{ƒ|ƒŠƒtƒFƒm[ƒ‹Šw‰ïŽ@(2016)‘à
  • Œã“¡„A‰Í“cÆ—Y
  • ¶ŠˆKŠµ•a‚Ɖh—{ Fu¶ŠˆKŠµ•a‚Æ‹@”\«H•i v
    CLINICAL CALCIUM @2016”N‚RŒŽ†

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
  • 2018
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  • 2016
  • 2015
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  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2015”NŒ¤‹†‹ÆÑ

    Goto T, Takahashi N, Kawada T.
  • Food Components Modulate Obesity and Energy Metabolism via the Transcriptional Regulation of Lipid-Sensing Nuclear Receptors.
    J Nutr Sci Vitaminol (Tokyo). (2015) 61: S128-130.
  • Kim MJ, Goto T, Yu R, Uchida K, Tominaga M , Kano Y , Takahashi N, Kawada T.
  • Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the 2 sympathetic nervous system
    Scientific Reports (2015) Dec 17; 5:18013.
  • Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A. Lai, Junne-Ming Sung, and Yau-Sheng Tsai.
  • Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
    Disease Models & Mechanisms, (2015) 8, 1311-1321.
  • Kim CS, Kwon Y, Choe SY, Hong SM, Yoo H, Goto T, Kawada T, Choi HS, Joe Y, Chung HT, Yu R.
  • Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1
    Nutr Metab (Lond). 2015 Oct 6;12:33
  • Takahashi H, Kamakari K, Goto T, Hara H, Mohri S, Nakata R, Inoue H, Suzuki H, Shibata D, Takahashi N, Kawada T.
  • 9-oxo-10(E),12(Z),15(Z)-octadecatrienoic acid activates peroxisome proliferator-activated receptor-ƒ¿ in hepatocytes
    Lipids. (2015) 50:1083-1091.
  • Nanthirudjanar T, Furumoto H, Zheng J, Kim YI, Goto T, Takahashi N, Kawada T, Park SB, Hirata A, Kitamura N, Kishino S, Ogawa J, Hirata T, Sugawara T.
  • Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes
    Lipids. (2015) 50:1093-1102.
  • Taketani K, Hoshino S, Uemura T, Goto T, Takahashi N, Tsuge N, Kawada T.
  • An efficient purification method for quantitative determinations of protodioscin, dioscin and diosgenin in plasma of fenugreek-fed mice.
    J. Nutr. Sci. Vitaminol. 2015;61(6):465-70.
  • Matsumoto H, Ushimaru S, Matsuda T, Shimada T, Mikuri M, Takahashi H, Takahashi N, Kawada T, Yamazaki T.
  • Is Caffeine Abstention Necessary before Adenosine-Induced Fractional Flow Reserve Measurement?
    J. Amer. Coll. of Cardiol. (2015) 66:1943-1945.
  • Goto T, Kim YI, Furuzono T, Takahashi N, Yamakuni K, Yang HE, Li Y, Ohue R, Nomura W, Sugawara T, Yu R, Kitamura N, Park SB, Kishino S, Ogawa J, Kawada T.
  • 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARgamma and stimulates adipogenesis.
    Biochem Biophys Res Commun. (2015) 459: 597-603.
  • Kim YI, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T.
  • Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages
    Biosci Biotechnol Biochem (2015) 79:82-87.
  • Tu T H, Kim C-S, Nam-Goong I S, Nam C K, Kim YI, Goto T, Kawada T, Park T, Yoon P, Jung H, Ryoo Z Y, Park J W, Choi H-S, Yu R.
  • 4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages
    FEBS J@(2015) 282:1468-1480.
  • Takahashi H, Hara H, Goto T, Kamakari K, Wataru N, Mohri S, Takahashi N, Suzuki H, Shibata D, Kawada T.
  • 3-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-@Activated Receptor ƒÁ in Adipocytes.
    Lipids (2015) 50:3-12.
  • Takahashi H, Goto T, Yamazaki Y, Kamakari K, Hirata M, Suzuki H, Shibata D, Takahashi N, Kawada T.
  • Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptorƒ¿
    J Lipid Res. (2015)56:254-265.
  • Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E.
  • Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-ƒÁ activation.
    Biochem Biophys Res Commun. (2015);457:23-30.
  • ‰Í“cÆ—YA‚‹´M”VAŒã“¡„
  • wH•iˆöŽq‚É‚æ‚é‰h—{‹@”\§Œäx‘æ3ÍuŽ‰–bEƒGƒlƒ‹ƒM[‘ãŽÓ‚ƃÀ-ƒNƒŠƒvƒgƒLƒTƒ“ƒ`ƒ“v
    Œš›åŽÐ@“Œ‹ž (2015)
  • Œã“¡„A‰Í“cÆ—Y
  • ”ì–žÇ‚̐HŽ–—Ö@Še˜_FuR”ì–ž‹@”\«H•i‚ÌŒ»ó‚Æ“W–]v
    w—Տ°‰h—{x‘æ127Šª4† (2015”NH‘Š§†)

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2014”NŒ¤‹†‹ÆÑ

    Le N H, Kim C-S, Park T, Park J H, Sung M-K, Lee D G, Hong S-M, Goto T, Kawada T, Yu R.
  • Quercetin Protects Against Obesity-Induced Skeletal Muscle Inflammation and Atrophy.
    Mediators of Inflammation. (2014);2014:834294.
  • Yoshino S, Kim M, Awa R, Kuwahara H, Kano Y, Kawada T.
  • Kaempferia parviflora extract increases energy consumption through activation of BAT in mice.
    Food Science & Nutrition (2014)2:634-7.
  • Yamamoto T, Takahashi H, Suzuki K, Hirano A, Kamei M, Goto T, Takahashi N, Kawada T.
  • Theobromine Enhances Absorption of Cacao Polyphenol in Rats.
    Biosci Biotechnol Biochem. (2014)78:2059-2063.
  • Hien Tu T-H, Kim C-S, Kang J-H, Nam-Goong I, Nam G, Kim E-S, Kim Y-I, Choi J-I, Kawada T, Goto T, Park T, Choi MS, Yu R.
  • Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters.
    Int J Obesity (2014) 38: 1075-1082.
  • Takahashi H, Kamakari K, Suzuki H, Mohri S, Goto T, Takahashi N, Matsumura Y, Shibata D, Kawada T.
  • Localization of 9- and 13-oxo-octadecadienoic acids in tomato fruit.
    Biosci. Biotechnol. Biochem. (2014)78:1761-1764.
  • Moriwaki S, Murakami H, Takahashi N, UemuraT, Taketani K, HoshinoS, Tsuge N, Goto T, Kawada T.
  • Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.
    Biosci. Biotechnol. Biochem. (2014)78:1231-1236.
  • Nagai H, Kawada T, Goto T, Kusudoh T, Tanaka T, Takahashi N.
  • Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.
    Biosci. Biotechnol. Biochem. (2014)78:296-300.
  • Hirai S, Ohyane C, Kim Y-I, Lin S, Goto T, Takahashi N, Kim C-S, Kang J, Yu R, Kawada T.
  • Involvement of mast cells in adipose tissue fibrosis.
    Am J Physiol. Endocrinology and Metabolism (2014) 306:E247-255.
  • Sakamoto T, Takahashi N, Goto T, Kawada T.
  • Dietary factors evoke thermogenesis in adipose tissues.
    Obesity Research & Clinical Practice (2014)8:e533-539.
  • ‰Í“cÆ—Y
  • ”ì–ž‚ÆŽ‰–bEƒGƒlƒ‹ƒM[‘ãŽÓ‚ÉŠÖ‚·‚éH•i‹@”\Šw“IŒ¤‹† (•½¬25”N“x“ú–{‰h—{EH—ÆŠw‰ïÜŽóÜ)
    “ú–{‰h—{EH—ÆŠw‰ïŽ@‘à (2014) 67Šª3†
  • –Ñ—˜W•ãA‰Í“cÆ—Y
  • Ž‰–bŽ_‚Ì–£—́AÄ”­Œ©
    Functional Food@(2014)8:114 -116
  • –Ñ—˜W•ãA‰Í“cÆ—Y
  • ƒgƒ}ƒg—R—ˆƒIƒLƒ\Ž‰–bŽ_Foxo-octadecadienoic acid (oxo-ODA)
    ˆãŠw‚Ì‚ ‚ä‚݁@ˆóü’†

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
  • 2018
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  • 2016
  • 2015
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  • 2013
  • 2012
  • 2011
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  • 2008
  • 2007

2013”NŒ¤‹†‹ÆÑ

    Kimura R, Takahashi N, Lin S, Goto T, Murota K, Nakata R, Inoue H, Kawada T.
  • DHA attenuates postprandial hyperlipidemia via activating PPARalpha in intestinal epithelial cells.
    J Lipid Res. (2013)54:3258-3268.
  • Kimura R, Takahashi N, Goto T, Murota K, Kawada T.
  • Activation of peroxisome proliferator-activated receptor-ƒ¿ (PPARƒ¿) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice.
    Obes Res Clin Pract. (2013)7:e353-360.
  • Le N. H, Kim C-S, Tu T. H, Choi H. S, Kim B-S, Kawada T, Goto T, Park T, Park J.H.Y, Yu R.
  • Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation.
    Mediators of Inflammation (2013);2013:865159.
  • Matsuura N, Gamo K, Miyachi H, Iinuma M, Kawada T, Takahashi N, Akao Y, Tosa H.
  • ƒÁ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARƒ¿ and PPARƒÂ.
    Biosci Biotechnol Biochem. (2013) 77:2430-2435.
  • Takahashi H, Suzuki H, Suda K, Yamazaki Y, Takino A, Kim Y-I, Goto T, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • Long-chain free fatty acid profiling analysis by liquid chromatography - mass spectrometry in mouse treated with peroxisome proliferator-activated receptor ƒ¿.
    Biosci. Biotechnol. Biochem. (2013) 77(11):2288-93.
  • Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, Nishimori K.
  • Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice.
    Endocrinology (2013) 154:4305-4315.
  • Yoshida H, Kanamori Y, Asano H, Hashimoto O, Murakami M, Kawada T, Matsui T, Funaba M.
  • Regulation of brown adipogenesis by the Tgf-ƒÀ family: Involvement of Srebp1c in Tgf-ƒÀ- and Activin-induced inhibition of adipogenesis.
    Biochim Biophys Acta. (2013)10;1830(11):5027-5035.
  • Lin S, Hirai S, Yamaguchi Y, Goto T, Takahashi N, Tani F, Mutoh C, Sakurai T, Murakami S, Yu R, Kawada T.
  • Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.
    Mol Nutr Food Res. (2013) 57:2155-2165.
  • Takahashi N, Yao L, Kim M, Sasako H, Aoyagi M, Shono J, Tsuge N, Goto T, Kawada T.
  • Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-ƒ¿ (PPAR-ƒ¿) activation in diabetic obese mice.
    Mol Nutr Food Res. (2013) 57:1295-1299.
  • Sakamoto T, Takahashi N, Sawaragi Y, Naknukool S, Yu R, Goto T, Kawada T.
  • Inflammation induced by RAW macrophages suppresses the UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes.
    Am J Physiol Cell Physiol. (2013) 304:C729-738.
  • Lin S, Hirai S, Goto T, Sakamoto T, Takahashi N, Yano M, Sasaki T, Yu R, Kawada T.
  • Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 MAPK activation
    Mol Nutr Food Res. (2013) 57:1135-1144.
  • Goto T, Kim YI, Takahashi N, Kawada T.
  • Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.@Review
    Mol Nutr Food Res. (2013) 57(1):20-33.
  • Goto T, Mori A, Nagaoka S.
  • Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells.
    Mol Nutr Food Res. (2013) 57:1435-1445.
  • Kawai R, Ito S, Aida T, Hattori H, Kimura T, Furukawa T, Mori K, Sanbuissho A, Kawada T.
  • Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats.
    J Immunotoxicol. (2013) 10: 40-48.
  • Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
  • Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet.
    J Nutr Biochem. (2013) 24: 887-893.
  • â–{’q–íA‚‹´M”VAŒã“¡„A‰Í“cÆ—Y
  • ŠŒFŽ‰–b‘gD‚̐¶—“I–ðŠ„‚Æ‹@”\§Œä
    ×–EHŠwi2013jVol.32. No.7, 2-7.
  • ‹à‰pˆêA‰Í“cÆ—Y
  • ƒgƒ}ƒg‚©‚猩o‚³‚ꂽŽ‰Ž¿‘ãŽÓ‰ü‘P¬•ªoxo-ODA
    ˆãŠw‚Ì‚ ‚ä‚Ý(2013) 244:1063-1064.
  • ‚‹´M”VAŒã“¡„A‰Í“cÆ—Y
  • ƒŠƒRƒyƒ“‚ÌŒø‰Ê
    “à•ª”åE“œ”A•aE‘ãŽÓ“à‰È(2013) 36(4):317-322
  • ‰Í“cÆ—Y@•Ò’˜
  • Ž‰–b‚ÌŒ÷ß‚ÆŒ’N@‘Ð@2013”N@Œš›åŽÐ”­s

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
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  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2012”NŒ¤‹†‹ÆÑ

    Goto T, Takahashi N, Kato S, Kim YI, Kusudo T, Taimatsu A, Egawa K, Kang MS, Hiramatsu T, Sakamoto T, Uemura T, Hirai S, Kobayashi M, Horio F, Kawada T.
  • Bixin Activates PPARƒ¿ and Improves Obesity-Induced Abnormalities of Carbohydrate and Lipid Metabolism in Mice.
    J Agric Food Chem. (2012) 60(48):11952-8. doi: 10.1021/jf303639f.
  • Le NH, Shin S, Tu TH, Kim CS, Kang JH, Goto T, Kawada T, Han SN, Yu R.
  • Diet enriched with korean pine nut oil improves mitochondrial oxidative metabolism in skeletal muscle and brown adipose tissue in diet-induced obesity.
    J Agric Food Chem. (2012) 60(48):11935-41. doi: 10.1021/jf303548k.
  • Tu TH, Kim CS, Goto T, Kawada T, Kim BS, Yu R.
  • 4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages.
    Mediators Inflamm. (2012);2012:972629. doi: 10.1155/2012/972629.
  • Sugiura C, Nishimatsu S, Moriyama T, Ozasa S, Kawada T, Sayama K.
  • Catechins and Caffeine Inhibit Fat Accumulation in Mice through the Improvement of Hepatic Lipid Metabolism.
    J Obes. (2012) 2012:520510.
  • Kuroda M, Mimaki Y, Ohtomo T, Yamada J, Nishiyama T, Mae T, Kishida H, Kawada T.
  • Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK-A(y) mice and identification of the active ingredients.
    J Nat Med. (2012) 66(2):394-399. doi: 10.1007/S11418-011-0593-Z
  • Goto T, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Kim YI, Hirai S, Uemura T, Yu R, Takahashi N, Kawada T.
  • Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.
    J. Nutr. Biochem. (2012) 23(7):768-776. doi: 10.1016/j.jnutbio.2011.04.001
  • Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K.
  • Soymorphin-5, a soy-derived ƒÊ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARƒ¿ systems in diabetic KKAy mice.
    Am. J. Physiol. - Endocrinology and Metabolism (2012) 302: E433-40.
  • Kim YI, Hirai S , Goto T , Ohyane C , Takahashi H , Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • Potent PPARƒ¿ Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice.
    PLoS ONE 7: e31317. doi:10.1371/journal.pone.0031317
  • Lee J-Y–, Takahashi N–, Yasubuchi M, Kim Y-I, Hashizaki H, Kim M-J, Sakamoto T,Goto T, Kawada T.
  • Triiodothyronine Induces UCP1 Expression and Mitochondrial Biogenesis in Human Adipocytes.
    Am. J. Physiol. - Cell Physiology (2012) 302:C463-72. (* equal contributions)
  • ‹à‰pˆêAŒã“¡„A–Ø‘º—œ”TA‚‹´M”VA‰Í“cÆ—Y
  • H•i‚Ɣ얞GŠj“àŽó—e‘̃ŠƒKƒ“ƒh‚É‚æ‚é‘ãŽÓ§Œä
    ƒJƒŒƒ“ƒgƒeƒ‰ƒs[ (2012) 30, 531-535.
  • ‰Í“cÆ—YAâ–{’q–í
  • ŠŒFŽ‰–bFŽ‰–b”RÄ‚ƐH•i‹@”\
    TŠ§ˆãŠw‚Ì‚ ‚ä‚Ý (2012)@242Šª12†@942-946.

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
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  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2011”NŒ¤‹†‹ÆÑ

    Goto T, Takahashi N, Funakoshi K, Kim Y-I, Teraminami A, Uemura T, Hirai S, Lee J-Y, Makishima M, Nakata R, Inoue H, Senju H, Matsunaga M, Horio F, Kawada T.
  • Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARƒ¿-dependent and -independent pathways.
    Am. J. Physiol. - Endocrinology and Metabolism (2011) 301: E1022-32.
  • Takahashi N, Senda M, Lin S, Goto T, Yano M, Sasaki T, Murakami S, Kawada T.
  • Auraptene regulates gene expression involved in lipid metabolism through PPAR-alpha activation in diabetic obese mice.
    Mol Nutr & Food Res. (2011) 58:1791-1797.
  • Goto T, Nagai H, Egawa K, Kim Y-I, Kato S, Taimatsu A, Sakamoto T, Hirai S, Ebisu S, Hohsaka T, Miyagawa H, Murakami S, Takahashi N, Kawada T.
  • Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARgamma agonist.
    Biochem J. (2011) 438: 111-119.
  • Matsumura T, Kinoshita H, Ishii N, Fukuda K, Motoshima H, Senokuchi T, Taketa K, Kawasaki S, Nishimaki-Mogami T, Kawada T, Nishikawa T, Araki E.
  • Telmisartan Exerts Antiatherosclerotic Effects by Activating Peroxisome Proliferator-Activated Receptor-gamma in Macrophages.
    Arterioscler Thromb Vasc Biol. (2011) 31: 1268-75.
  • Kim CS, Kim JG, Lee B-J, Choi M-S, Choi H-S, Kawada T, Lee K-U, Yu R.
  • Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders.
    Diabetes (2011) 60:3159-68.
  • Ikeda R, Yanagisawa M, Takahasshi N, Kawada T, Kumazawa S, Yamaotsu N, Nakagome I, Hirono S and Tsuda T.
  • Brazilian propolis-derived components inhibit TNF-alpha-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
    Biochim. Biophys. Acta. (2011) 1810: 695-703.
  • Takahashi H, Kim IL, Hirai S, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • Comparative and stability analyses of 9- and 13-oxo-octadecadienoic acid in various species of tomato.
    Biosci. Biotechnol. Biochem. (2011) 75: 1621-4.
  • Kim HJ, Kim HM, Kim CS, Jeong CS, Choi HS, Kawada T, Kim BS, Yu R.
  • HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance.
    FEBS Lett. (2011) 585:2285-2290.
  • Kang JH, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R
  • Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice.
    J Med Food. (2011) 14: 310-315.
  • Kimura R, Takahashi N, Murota K, Yamada Y, Kanzaki N, Murakami Y, Goto T, Kawada T.
  • Activation of peroxisome proliferator-activated receptors induces intestinal fatty acid-oxidation to suppress lipid absorption.
    Biochem. Biophys. Res. Commun. (2011) 410: 1-6.
  • Nagai H, Goto T, Takahashi N, Deyashiki Y, Esaka Y, Kawada T.
  • A method for simultaneous determination of 3T3-L1 adipocyte metabolites by liquid chromatography/mass spectrometry using a 13[C]-stable isotopes.
    Biosci. Biotechnol. Biochem. (2011) 75: 1485-9.
  • Sakamoto T*, Yamaguchi Y*, Goto T, Takahashi N, Kawada T.
  • An in vitro analysis system using a fluorescence protein reporter for evaluating anti-inflammatory effects in macrophages.
    Biosci. Biotechnol. Biochem. (2011) 75: 1582-7. (* equal contributions)
  • Takahashi N*, Yao R*, Kang MS*, Senda M, Nishimura K, Hirai S, Yu R, Goto T, Ezaki Y, Kawada T.
  • Dehydroabietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) to regulate gene expression involved in adipogenesis of 3T3-L1 adipocytes.
    BioFactors (2011) 37: 309-14. (* equal contributions)
  • Lee JY, Hashizaki H, Goto T, Sakamoto T, Takahashi N, Kawada T.
  • Activation of PPAR-alpha enhances fatty acid oxidation in human adipocytes.
    Biochem. Biophys. Res. Commun. (2011) 407: 818-822.
  • Goto T, Lee J-Y, Teraminami A, Kim Y-I, Hirai S, Uemura T, Inoue H, Takahashi N, Kawada T.
  • Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes.
    J Lipid Res. (2011) 52: 873-884.
  • Nagai H, Ebisu S, Abe R, Goto T, Takahashi N, Hohsaka T, Kawada T.
  • Development of a novel PPARgamma ligand screening system using pinpoint fluorescence-probed protein.
    Biosci. Biotechnol. Biochem. (2011) 75: 337-341.
  • Uemura T, Goto T, Kang M-S, Mizoguchi N, Hirai S, Lee, J-Y, Nakano Y, Shono J, Hoshino S, Taketani K, Tsuge N, Narukami T, Makishima M, Takahashi N, Kawada T.
  • Diosgenin, the Main Aglycon of Fenugreek, Inhibits LXRƒ¿ Activity in HepG2 cells and Decreases Plasma and Hepatic Triglycerides in Obese, Diabetic Mice.
    J. Nutr. (2011) 141: 17-23.
  • Kim Y-I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
  • 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent peroxisome proliferator-activated receptor ƒ¿ agonist to decrease triglyceride accumulation in mouse primary hepatocytes.
    Mol. Nutr. Food Res. (2011) 55: 585-593.
  • ‰Í“cÆ—Y
  • ƒJƒvƒTƒCƒVƒ“‚Ì‹@”\«‚ðŠw‚Ú‚¤@
    ŒŽŠ§uH¶Šˆv2011”N7ŒŽ†
  • ‰Í“cÆ—Y
  • Šª“ªŒ¾FŽ‰–b×–E ‚Ó‚é‚«‚ðq‚ˁA‚ ‚½‚炵‚«‚ðŠÏ‚é
    ”ì–žŒ¤‹† 201‚P”N1†
  • Œã“¡„A—›Žü—eA‚‹´M”VA‰Í“cÆ—Y
  • ƒƒ^ƒ{ƒŠƒbƒNƒVƒ“ƒhƒ[ƒ€[Šî‘bE—Տ°‚̍ŐV’mŒ©-@‘æ‚Q”Ł@ƒƒ^ƒ{ƒŠƒbƒNƒVƒ“ƒhƒ[ƒ€”­ÇŠî”Õ‚Æ‚µ‚Ä‚ÌŽ‰–b×–E‹@”\ˆÙíFŽ‰–b×–E‚̃‰ƒCƒtƒTƒCƒNƒ‹‚Æ‚»‚̐§ŒäˆöŽq
    “ú–{—Õଠiˆóü’†j
  • ‰Í“cÆ—YA‘åŽR‰Ä“ށA‚‹´M”V
  • ƒÀ-ƒNƒŠƒvƒgƒLƒTƒ“ƒ`ƒ“[“œEŽ‰Ž¿‘ãŽÓ‰ü‘Pì—p
    Functional Food (2011) 4: 294-299
  • ‰Í“cÆ—YA‚‹´M”VAŒã“¡„
  • ŠŒFŽ‰–bŒ¤‹†‚̐V“WŠJF‘Ì”MŽY¶EŠŒFŽ‰–b‹@”\‚ƐH•iˆöŽq
    ”ì–žŒ¤‹†@(2011) 17: 96-101
  • ‰Í“cÆ—Y
  • ŠŒFŽ‰–bEUCP1‚ðŠˆ«‰»‚³‚¹‚鎉–bŽ_‚Í‚ ‚è‚Ü‚·‚©H
    ”ì–ž‚Æ“œ”A•a (2011) 10: ˆóü’†

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2010”NŒ¤‹†‹ÆÑ

    Kang J-H, Goto T, Han I-S, Kim C-S, Kawada T, Kim Y-M, Yu R.
  • Dietary Capsaicin reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice fed a High-fat Diet.
    Obesity (2010) 18: 780-787.
  • Kim CS, Tu TH, Kawada T, Kim BS, Yu R.
  • The Immune Signaling Molecule 4-1BB Stimulation Reduces Adiposity, Insulin Resistance, and Hepatosteatosis in Obese Mice.
    Endocrinology. (2010) 151: 4725-4735.
  • Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E.
  • Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.
    Arterioscler Thromb Vasc Biol. (2010) 30: 1598-15605.
  • Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, Taketani K, Nakano Y, Shono J, Hoshino S, Tsuge N, Narukami T, Takahashi N, Kawada T.
  • Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
    Mol. Nutr. Food Res. (2010) 54: 1596-1608.
  • Inoue, H., Takahashi, N., Okada, Y. and Konishi, M.
  • Volume-sensitive outwardly rectifying chloride channel in white adipocytes. Am.
    J. Physiol.: Cell Physiol. (2010) 298: C900-C909.
  • Goto T, Takahashi N, Hirai S, Kawada T.
  • Various terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism.
    PPAR Res. (2010) 2010: 483958.
  • Hirai S, Takahashi N, Goto T, Lin S, Uemura T, Yu R, Kawada T.
  • Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.
    Mediators Inflamm. (2010) 2010: 367838.
  • Fujitani Y, Aritake K, Kanaoka Y, Goto T, Takahashi N, Fujimori K, Kawada T.
  • Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.
    FEBS J. (2010) 277: 410-419.
  • Hirai, S.*, Uemura, T.*, Mizoguchi, N., Lee, J. Y., Taketani, K., Nakano,Y., Hoshino, S., Tsuge, N., Narukami, T., Yu, R., Takahashi, N. and Kawada,T.
  • Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages.
    Mol. Nutr. Food Res. (2010) 54: 1-8. (* equal contributions)
  • Œã“¡„A—›Žü—eAŽ›“숟‹IA‚‹´M”VA‰Í“cÆ—Y
  • ”ì–žÇi‘æ‚Q”ŁjF‰h—{‘f‚É‚æ‚éƒGƒlƒ‹ƒM[‘ãŽÓ’²ß@wŽ‰–b×–E‚Å‚Ì‘ãŽÓ’²ßx
    “ú–{—Õଁ@‘Š§†@(2010) 156-161.
  • ‰Í“cÆ—Y
  • Šª“ªŒ¾FŽ‰–b×–EŽ]‰Ì
    The Lipid 2010”N1ŒŽ†
  • ‚‹´M”VA‰Í“cÆ—Y
  • ƒ}ƒbƒL[¶‰»Šwi‘æ4”Łj‘æ16Íu‘ãŽÓ‚Ì“‡“I—‰ðv–|–ó
    ‰»Šw“¯li2010j

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2009”NŒ¤‹†‹ÆÑ

    Takahashi N*, Goto T*, Taimatsu A, Egawa K, Katoh S, Kusudo T, Sakamoto T, Ohyane C, Lee J.Y., Kim Y.I., Uemura T, Hirai S, and Kawada, T.
  • Bixin regulates gene expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPAR-gamma activation.
    Biochem. Biophys. Res. Commun. (2009) 390: 1372-1376. (* equal contributions)
  • Ando C*, Takahashi N*, Hirai S*, Lee J.Y., Goto T, Yu R, and Kawada T.
  • Luteolin, a food-derived flavonoid, inhibits adipocyte-dependent activation of macrophages in adipose tissues.
    FEBS Lett. (2009) 583: 3649-3654. (* equal contributions)
  • Kang M.S., Hirai S, Goto T, Kuroyanagi K, Kim I.Y., Ohyama K, Uemura T, Lee J.Y., Sakamoto T, Ezaki Y, Yu R, Takahashi N, and Kawada T.
  • Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation of mouse adipose tissues.
    BioFactors (2009) 35: 442-448.
  • Iwasaki K, Kamauchi S, Wadahama H, Ishimoto M, Kawada T, Urade R.
  • Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs.
    FEBS J. (2009) 276: 4130-4141.
  • Takahashi N, Goto T, Hirai S, Uemura T, and Kawada T.
  • Genome science of lipid metabolism and obesity.
    in: FOOD FACTORS for HEALTH PROMOTION (Dr. T. Yoshikawa, Kyoto, Japan), Forum Nutri. (2009) 61: 25-38.
  • Goto T, Hirai S, Yu R, Takahashi N, and Kawada T.
  • Obesity and Nuclear Receptors : Effective Genomic Strategies in Functional Foods.
    in: NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds) (2009) 47-58. WILEY-BLACK WELL
  • Goto T, Hirai S, Yu R, Takahashi N, and Kawada T.
  • Isoprenols : Effective Genomic Strategies in Functional Foods.
    in: NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds) (2009) 301-310. WILEY-BLACK WELL
  • Lee HS, Park JH, Kang JH, Kawada T, Yu R, Han IS
  • Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice.
    Cytokine. (2009) 46: 160-165.
  • Mochizuki Y, Maebuchi M, Kohno M, Hirotsuka M, Wadahama H, Moriyama T, Kawada T, Urade R.
  • Changes in lipid metabolism by soy beta-conglycinin-derived peptides in HepG2 cells.
    J Agric Food Chem. (2009) 57: 1473-1480.
  • ‚‹´M”VA‘åŽR‰Ä“ށAç“c^—¢A¼‘º‰Á“ÞŽqA‰Í“cÆ—Y
  • ƒJƒƒeƒmƒCƒh‚̉Ȋw‚ƍŐV‰ž—p‹Zp@‘æ11ÍuƒJƒ“ƒLƒc—R—ˆƒJƒƒeƒmƒCƒh‚Ì‹@”\«v
    ƒV[ƒGƒ€ƒV[o”Łi2009j

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2008”NŒ¤‹†‹ÆÑ

    Taketa K, Matumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T,Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E.
  • Ox-LDL activates PPARalpha and PPARgamma through MAPK-dependent COX-2 expression in macrophages.
    J Biol Chem. (2008) 283: 9852-9862.
  • Takahashi N, Kang M-S, Kuroyanagi K, Goto T, Hirai S, Ohyama K, Lee J-Y, Yu R, Yano M, Sasaki T, Murakami S, Kawada T.
  • Auraptene, a citrus fruit compound, regulates gene expression as a PPAR-alpha agonist in HepG2 hepatocytes.
    BioFactors. (2008) 33: 25-32.
  • Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
  • Oleuropein, a phenolic compound in etra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol (Tokyo). (2008) 54: 363-307.
  • Isa Y, Miyakawa Y, Yanagisawa M, Goto T, Kang MS, Kawada T, Morimitsu Y, Kubota K, Tsuda T.
  • 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanism in 3T3-L1 adipocytes.
    Biochem Biophys Res Commun. (2008) 373: 429-434.
  • Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K.
  • Oxytocin receptor-deficient mice developed late onset obesity.
    Neuro Report. (2008) 19: 951-955.
  • Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T.
  • Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in Macrophages and adipocytes to regulate inflammation.
    Biochem Biophys Res Commun. (2008) 369: 333-338.
  • Kawada T, Goto T, Hirai S, Kang M-S, Uemura T, Yu R, Takahashi N.
  • Dietary regulation of nuclear receptors in obesity-related metabolic syndrome.
    Asia Pac J Clin Nutr. (2008) 17(Suppl): 126-130.
  • Kuroyanagi K, Kang MS, Goto T, Hirai S, Ohyama K, Kusudo T, Yu R, Yano M, Sasaki T, Takahashi N, Kawada T.
  • Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocyte.
    Biochem Biophys Res Commun. (2008) 366: 219-225.
  • Kim C-S, Lee SC, Kim BS, Kim YM, Kawada T, Kwon B-S Yu R.
  • Visceral fat accumlation causes the atrophy of mesenteric lymph nodes in obese mice fed a high-fat diet.
    Obesity. (2008) 16: 1261-1269.
  • Kang JH, Han IH, Sung MK, Yoo H, Kim YG, Kim JS, Kawada T, Yu R.
  • Soybean saponin inhibits tumor cell metastasis by modulating expression of MMP-2, MMP-9 and TIMP-2.
    Cancer Lett. (2008) 261: 84-92.
  • Wadahama H, Kamauchi S, Nakamoto Y, Nishizawa K, Ishimoto M, Kawada T, Urade R.
  • A novel plant protein disulfide isomerase family homologous to animal P5: molecular cloning and characterization as a functional protein for folding of soybean seed storage protein.
    FEBS J. (2008) 275: 399-410.
  • ‰Í“c Æ—YAŒã“¡ „A•½ˆä ÃA‚‹´ M”V
  • Ž‰Ž¿‘ãŽÓ‚Ɛ¶ŠˆKŠµ•aEƒƒ^ƒ{ƒŠƒbƒNƒVƒ“ƒhƒ[ƒ€
    ¶•¨HŠw@(2008)@86: 469-487.
  • •½ˆä ÃAŒã“¡ „A–ö —œ›PA‚‹´ M”VA‰Í“c Æ—Y
  • ”ì–ž‚ÆŽ‰–bƒGƒlƒ‹ƒM[‘ãŽÓF”ì–žEƒƒ^ƒ{ƒŠƒbƒNƒVƒ“ƒhƒ[ƒ€‚ƐH•i‹@”\
    Œš›åŽÐ@(2008)
  • ‰Í“c Æ—Y
  • ‰h—{ŠwŒ¤‹†‚̍őOüF•a‘Ô‰h—{•ª–ì‚̐i•à‚Ɖۑè
    Œš›åŽÐ@(2008)
  • ‰Í“c Æ—Y
  • H•i‹@”\«‚̉ȊwFh–¡¬•ª‚¨‚æ‚уtƒBƒgƒPƒ~ƒJƒ‹
    ŽY‹Æ‹ZpƒT[ƒrƒXƒZƒ“ƒ^[@(2008)
  • ‰Í“c@Æ—Y
  • ”ì–žEƒƒ^ƒ{ƒbƒŠƒbƒNƒVƒ“ƒhƒ[ƒ€‚ƐH•i
    ƒlƒXƒŒ‰h—{‰ÈŠwƒŒƒrƒ…[ihttp://www.nestle.co.jp/science/review/review0712.htmj

ƒy[ƒWƒgƒbƒv‚Ö

  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007

2007”NŒ¤‹†‹ÆÑ

    Kasahara Y, Takayanagi Y, Kawada T, Itoi K, Nishimori K.
    Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure.
    Biosci Biotechnol Biochem. (2007) 71: 3122-3126. Sakane N, Kotani K, Hioki C, Yoshida T, Kawada T.
  • Up-regulation of muscle uncoupling protein 3 gene expression by calcium channel blocker, Benidipine Hydrochloride in rats.
    Endocr. J. (2007) 54: 771-775.
  • Hirai S, Kim Y-I, Goto T, Kang M-S, Yoshimura M, Obata A, Yu R, Kawada T.
  • Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages.
    Life Sci. (2007) 81: 1272-1279.
  • Kang J-H, Kim C-S,Han I-S, Kawada T, Yu R.
  • Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages.
    FEBS Letters (2007) 581: 4389-439
  • Yano Y, Matsumura T, Senokuchi T, Ishii N, Motoshima H, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Sakai M, Kawada T, Nishikawa T, Araki E.
  • Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: Impact of the suppression of nuclear translocation of ERK1/2.
    Atherosclerosis (2007) 191: 22-32.
  • Yano Y, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada K, Brownlee M, Nishikawa T, Araki E.
  • Statins Activate Peroxisome Proliferator-Activated Receptor ƒÁ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependet Cyclooxygenase-2 Expression in Macrophages.
    Circ. Res. (2007) 100: 1442-1451.
  • Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai K.
  • Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue, and enhances noradrenaline and adrenaline secretion in rats.
    J Nutr Biochem. (2007) 18: 685-692.
  • Woo H-M , Kang J-H , Kim C-S, Kawada T, Yoo H, Sung M-K, Yu R.
  • Spices-derived active components inhibit obesity-induced inflammatory responses by modulating the behavior of adipose tissue macrophages and the release of MCP-1 from adipocytes.
    Life Sci. (2007) 80: 926-931.
  • Kawachi H, Moriya NH, Korai T, Tanaka S, Watanabe M, Matsui T, Kawada T, Yano H.
  • Nitric oxide suppresses preadipocyte differentiation in 3T3-L1 culture.
    Mol. Cell. Biochem. (2007) 300: 61-67.
  • Kondoh Y, Teruo Kawada, Reiko Urade.
  • Activation of caspase 3 in HepG2 cells by elaidic acid (t18:1) Biochim.
    Biophys Acta (2007) 1771: 500-505.
  • Urade R
  • Cellular response to unfolded proteins in the endoplasmic reticulum of plants.
    FEBS Journal (2007) 102: 225-231.
  • Wadahama H, Kamauchi S, Ishimoto M, Kawada T and Urade R
  • Protein disulfide isomerase family proteins involved in soybean protein biogenesis.
    FEBS Journal (2007) 274: 687-703.
  • Ukai T and Urade R
  • Cooperation of phosphatidylcholine with endogenous lipids of wheat flour for an increase in dough@volume.
    Food Chemistry (2007) 102: 225-231
  • A‘º ‘ìAŒã“¡ „A‰Í“c Æ—Y
  • R”ì–žH•iE‘fÞ‚ÌŠJ”­‚Ɖž—p“WŠJGR”ì–ž‚̃ƒJƒjƒYƒ€
    ƒV[ƒGƒ€ƒV[o”Ł@(2007)
  • Œã“¡ „AA‘º ‘ìA‘ºã —zŽqA‰Í“c Æ—Y
  • ƒƒ^ƒ{ƒŠƒbƒNÇŒóŒQ‚Ɖh—{Fƒƒ^ƒ{ƒŠƒbƒNÇŒóŒQ‚ƐH•i‹@”\[“œ”A•aŠÖ˜A
    K‘–[ (2007) 175-187.
  • •½ˆä ÃA“í“° ’B–çAŒüˆä ²‹PŽqA‰Í“c Æ—Y
  • ”|—{Ž‰–b×–E‚Ì•ª‰»ƒvƒƒgƒR[ƒ‹Au“œ”A•aƒJƒŒƒ“ƒgƒ‰ƒCƒuƒ‰ƒŠ[v
    •¶Œõ“° (2007) 276-279.
  • Meet the Professor-13 Dr. Christian Dani
  • ƒqƒgŽ‰–b‘gD—R—ˆ‘½”\«Š²×–E(hMADS)‚ÌŠm—§‚Æ‚»‚̉ž—pŒ¤‹†C‚¨‚æ‚ÑŽ‰–b×–E•ª‰»‚Æ”­’B‚̃L[•ªŽqC‚e‚f‚eC‚d‚q‚j‚Ì‹@\’Tõ
    Adiposcience (2007) 4: 88-95.

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